Top 5 Ketamine Scientific Articles of 2023

One of the best ways to equip yourself as a ketamine clinic owner is to know about the latest research on ketamine. Use this list as a guide to help you stay up-to-date on the top ketamine scientific articles of 2023.

Becoming a ketamine clinic owner means taking the time to learn more about ketamine therapy. This means reading up on the latest research and staying up-to-date. Due to the increasing number of ketamine research articles, it can be overwhelming to know where to start. In this blog, you’ll find a list of the top ketamine scientific articles of 2023 to guide and help jump-start your path to lifelong learning of ketamine. 

1. Antidepressant and anti-suicidal effects of ketamine in treatment-resistant depression associated with psychiatric and personality comorbidities: A double-blind randomized trial

Gellan K. Ahmed et al. Journal of Affective Disorders March 15, 2023

• This rigorous double-blind study involving 36 patients with Treatment-Resistant Depression (TRD) demonstrates that ketamine infusions result in a significant decrease in both depression and suicidal ideation, irrespective of the presence of other psychiatric and personality comorbidities. The findings underscore ketamine's potential as a versatile treatment option

2. A transdiagnostic systematic review and meta-analysis of ketamine’s anxiolytic effects

Hannah Hartland et al. Journal of Psychopharmacology April 2, 2023

• The systematic review and meta-analysis of 14 studies delve into ketamine’s potential as an anxiolytic treatment across various clinical settings. The findings showed ketamine significantly reduced anxiety scores compared to a placebo, and a correlation between improvements in anxiety and depression symptoms. 

3. Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression

Jared Kopelman et al. Translational Psychiatry May 9, 2023

• This randomized controlled trial involving 98 adults with treatment-resistant depression explored the rapid neuroplasticity changes induced by intravenous ketamine. The study identified associations between gray matter microstructural changes in key brain regions and improvements in depression scores. The findings suggest that ketamine's acute effects on depression could be partially mediated by detectable changes in neuroplasticity.

4. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression

Amit Anand et al. The New England Journal Of Medicine June 22, 2023

• This open-label, randomized, noninferiority trial compared the effectiveness of ketamine and Electroconvulsive Therapy (ECT). Ketamine demonstrated noninferiority to ECT, with a higher response rate and fewer impacts on memory recall. Both treatments showed similar improvements in patient-reported quality of life. ECT was associated with musculoskeletal and ketamine with dissociation in regards to adverse effects. These results highlight ketamine as a compelling alternative to ECT for nonpsychotic treatment-resistant depression.

5. Ketamine for the treatment of major depression: a systematic review and meta-analysis

Stevan Nikolin et al. EClinicalMedicine Aug 3, 2023 

• A comprehensive systematic review and meta-analysis of 49 randomized controlled trials investigated ketamine's efficacy in treating major depression. The findings suggested racemic ketamine had a greater effect on depression than esketamine, particularly at higher doses.

Use this list to equip you as you learn more about ketamine so you can educate others too. There is still a lot of misconception out there about the drug, so by shedding more light on ketamine therapy, you’ll be able to help others who want to get treated. There are hundreds of ketamine articles at your fingertips online, so always stay hungry for more knowledge as you start and move forward with your ketamine clinic journey. 

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One of the best ways to equip yourself as a ketamine clinic owner is to know about the latest research on ketamine. Use this list as a guide to help you stay up-to-date on the top ketamine scientific articles of 2023.

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