From our vault: Sam's complete clinical overview originally presented to UCLA and Betty Ford Fellowship. This foundational episode covers ketamine's 50-year history, NMDA receptor mechanism, patient selection criteria, dosing protocols, and safety considerations.

Dr. Randy Frederick, former military flight surgeon and ER physician, discusses his transformation from traditional clinical ketamine protocols to psychospiritual healing approaches. Learn why he views ketamine as a catalyst rather than cure, his insights on consciousness work, business ownership challenges, and the future of psychedelic medicine

ER physician Dr. Jack Hay and psychologist Dr. Harry Pepper share their unique partnership approach to ketamine therapy at Oberlin Ketamine Clinic. Topics include patient-chosen music playlists, trauma-informed care principles, integration coaching versus traditional therapy, practicing from values, and lessons from their first year opening a clinic in Ohio.

Learn which licenses you need to legally open a ketamine infusion clinic. This episode covers essential medical licenses like DEA and NPI, unfamiliar business permits including FNP and DBA, and why requirements vary significantly by state and county.

Retired DEA agent reveals audit triggers while an insurance expert shares costly coverage mistakes. Essential compliance and protection strategies every ketamine clinic owner needs to know.

Learn from three medical pioneers who refused to accept "no" as an answer. Dr. Howard Kornfeld revolutionized addiction treatment, Dr. Joe Tafur bridges traditional and modern healing, and Dr. Mel Herbert transformed global medical education. Their stories prove individual practitioners can create lasting systemic change.

Emergency physician Dr. Nico Grundmann shares his journey from ER doctor to CEO, scaling Ember Health from one pilot location to five ketamine clinics across New York City.

Dr. Howard Kornfeld shares five decades of medical insights, from emergency medicine and nuclear activism to pioneering buprenorphine treatment and building Recovery Without Walls clinic.

Kim and Sam Ko share their complete journey from hospital-employed physicians to successful ketamine clinic owners. Learn how they discovered ketamine research, managed the risks of leaving traditional employment, overcame social resistance, and built Reset Ketamine from four treatments in month one to a thriving practice.

Learn four essential mindset tools that separate successful ketamine clinics from those that struggle. Kim and Sam teach simple mnemonics for staying focused during chaos, prioritizing effectively, maintaining presence, and controlling negative thoughts that can derail your practice

Discover why individual ketamine therapy isn't enough and shares practical strategies for building healing communities that address systemic mental health challenges with Mike Margolies, co-founder of Global Psychedelic Society.

Learn the proven ACC marketing framework (Awareness, Consideration, Conversion). Discover how to create organic content that builds trust, dominate local search results, and use newsletters as your highest ROI marketing tool.

Discover essential insurance requirements for ketamine clinics from expert Canyon Clifton, including malpractice coverage, cyber liability protection, business insurance, and strategic claims prevention methods.

Explore essential patient preparation strategies for safer, more effective ketamine infusion experiences and improved clinical outcomes.

Explore the role of music in psychedelic and ketamine therapy, including music selection strategies, historical insights, and practical tips for clinicians supporting therapeutic journeys.

In this clinical deep dive, Sam shares the history, neuroscience, and protocols behind ketamine infusion therapy. Perfect for clinicians and providers, this episode outlines how ketamine works, ideal patient selection, dosing, and real-world treatment results for depression, PTSD, anxiety, and chronic pain.

In this episode, Sam and Kim Ko share the 3F Framework (Finances, Feelings, and Forces) to help you determine when it’s the right time to go full-time with your ketamine clinic. Whether you're juggling a current job or already seeing patients, this episode offers real talk, myths to bust, and actionable steps to make a confident, strategic decision.

In this special Season 1 finale of the Ketamine StartUp Podcast, we reflect on key episodes covering ketamine clinic business strategies, clinical best practices, physician wellness, and emerging psychedelic medicine trends. Whether you're catching up or revisiting favorites, we’ve got a guide to help. Tune in and get ready for an exciting Season 2 coming in April!